CLINICAL
TRIALS

CELLIANT® has 10 peer-reviewed, published
studies to date.

Man wearing a breathing mask and sensors while riding a stationary bike in a lab setting. A computer and testing equipment are visible beside him, indicating a fitness or performance test.

BACKED BY SCIENCE

While infrared has long been established as a wellness tool, Hologenix has revolutionized this technology with a modern twist: adding CELLIANT infrared minerals to textile products. We seek to simultaneously continue to establish and validate the science behind the efficacy of CELLIANT and IR textiles through our clinical research. To download a full report of CELLIANT clinical trials, click below, or scroll further for each individual report and a summary of key outcomes.

SUMMARY OF CLINICAL TRIALS

A central end point of the majority of our studies has been tissue oxygen (TcPO2) levels. Successful TcPO2 outcomes are indicators that CELLIANT effectively increases local circulation and cellular oxygenation, which form the basis of its full range of benefits. In further exploring these specific benefits, we have examined the interactions between infrared and biomarkers such as improving grip strength, sleep efficiency and increasing anaerobic threshold by lowering VO2. Significant findings of our peer-reviewed, published studies have been summarized below.

Year

2022

End Point

Tissue Oxygen (TCPO2) and Peripheral Blood Flow

Title

Randomized Placebo-Controlled Clinical Trial of Gloves and Stockings Made from Infrared-Emitting Fabric (CELLIANT®) for Transcutaneous Oxygen and Peripheral Blood Flow in Diabetic Patients with Vascular Impairment

Institution

Loyola University Chicago

Primary Investigators

Dr. Lawrence A. Lavery, Dr. Michael R. Hamblin and Kathryn Davis

N

20

Journal/Publication

Journal of Textile Science & Engineering

Outcome
Initial findings suggest evidence of improvement in peripheral blood flow of diabetic patients

Year

2021

End Point

Elbow and Wrist Pain

Title

Effect of CELLIANT® Armbands on Grip Strength in Grip Strength in Subjects with Chronic Wrist and Elbow Pain

Institution

Long Beach VA Memorial Hospital

Primary Investigators

Dr. Ian Gordon and Dr. Michael R Hamblin

N

70

Journal/Publication

Research Journal of Textile and Apparel

Outcome
Improved grip strength

Year

2019

End Point

Grip Strength

Title

Effect of Shirts with 42% CELLIANT® Fiber on tcPO2 Levels and Grip Strength in Healthy Subjects: A Placebo-Controlled Clinical Trial

Institution

Long Beach VA Memorial Hospital

Primary Investigators

Dr. Ian Gordon, Dr. Mark Vangel and Dr. Michael R Hamblin

N

24

Journal/Publication

Journal of Textile Science and Engineering

Outcome
Improved grip strength of over 12% in the dominant hand after 90 minutes

Year

2018

End Point

Tissue Oxygen (TCPO2)

Title

Randomized Controlled Trial Comparing the Effects of Far-Infrared Emitting Ceramic Fabric Shirts and Control Polyester Shirts on Transcutaneous PO2

Institution

Long Beach VA Memorial Hospital

Primary Investigators

Dr. Ian Gordon, James Wason, Dr. Lawrence Lavery, Dr. Michael R Hamblin and MS Thein

N

153

Journal/Publication

Journal of Textile Science and Engineering

Outcome
Average increase in TCPO2 of 8.4% after 90 minutes for 71% of the subjects

Year

2012

End Point

Tissue Oxygen (TCPO2)

Title

The Test Report on the Impacts of Subject Socks with the Application of CELLIANT® Technical Fibers on Transcutaneous Oxygen Pressure on a Man’s Foot

Institution

Academy of Chinese Sciences

Primary Investigators

Dr. Li Shaojing, Wu Chuanhong, Gao Jian, Zhu Li and Wen Liwei

N

100

Journal/Publication

N/A

Outcome
Increase in TCPO2 across all healthy subjects

Year

2012

End Point

Tissue Oxygen (TCPO2)

Title

Transcutaneous Partial Pressure of Oxygen (tcPO2) as a Primary Endpoint to Assess the Efficacy of CELLIANT® as a Vasoactive Material

Institution

Long Beach VA Memorial Hospital

Primary Investigators

Dr. Ian Gordon and Dr. Michael Coyle

N

51

Journal/Publication

N/A

Outcome
An average increase of 7% in TCPO2

Year

2011

End Point

Performance & Recovery

Title

Apparel with Far Infrared Radiation for Decreasing an Athlete’s Oxygen Consumption During Submaximal Exercise

Institution

University of Calgary

Primary Investigators

Dr. Jay Worobets, Dr. Darren Stefanyshyn and Emma Skolnik

N

12

Journal/Publication

Research Journal of Textile and Apparel
Outcome
Elite/club cyclists VO2 reduced by 1.1%, increasing anaerobic threshold

Year

2010

End Point

Sleep (pilot)

Title

Double Blind, Placebo Controlled, Crossover Trial on the Effect of Optically Modified Polyethylene Terephthalate Fiber Mattress Covers on Sleep Disturbances in Patients with Chronic Back Pain

Institution

University of CA Irvine

Primary Investigators

Dr. Marcel Hungs and Dr. Annabel Wang

N

6

Journal/Publication

N/A

Outcome
Nighttime awakenings, sleep quality and sleep efficiency improved

Year

2009

End Point

Foot Pain

Title

Effect of Optically Modified Polyethylene Terephthalate Fiber Socks on Chronic Foot Pain

Institution

University of CA Irvine

Primary Investigators

Dr. Ian Gordon and Dr. Robyn York

N

55

Journal/Publication

BioMed Central Complementary & Alternative Medicine
Outcome
Statistically significant reduction of pain and improved comfort for subjects (diabetic/foot neuropathy)

Year

2005

End Point

Tissue Oxygen (TCPO2)

Title

Holofiber Study of Thirteen (13) Healthy Subjects

Institution

University of Texas A&M

Primary Investigators

Dr. Graham McClue

N

13

Journal/Publication

N/A
Outcome

An average increase in TCPO2 levels from 10% to 24%

Year

2003

End Point

Tissue Oxygen (TCPO2)

Title

Improving Blood Flow with Holofiber in the Hands and Feet of High-Risk Diabetics

Institution

Loyola University Chicago

Primary Investigators

Dr. Lawrence Lavery

N

20

Journal/Publication

N/A
Outcome
An average increase in TCPO2 levels from 12% in the hands and 8% in the feet of diabetic subjects

Year

End Point

Title

Institution

Primary Investigators

N

Journal/Publication

Outcome

2022

Tissue Oxygen (TCPO2) and Peripheral Blood Flow

Randomized Placebo-Controlled Clinical Trial of Gloves and Stockings Made from Infrared-Emitting Fabric (CELLIANT®) for Transcutaneous Oxygen and Peripheral Blood Flow in Diabetic Patients with Vascular Impairment

Loyola University Chicago

Dr. Lawrence A. Lavery, Dr. Michael R. Hamblin and Kathryn Davis

20

Journal of Textile Science & Engineering

Initial findings suggest evidence of improvement in peripheral blood flow of diabetic patients

2021

Elbow and Wrist Pain

Effect of CELLIANT® Armbands on Grip Strength in Grip Strength in Subjects with Chronic Wrist and Elbow Pain

Long Beach VA Memorial Hospital

Dr. Ian Gordon and Dr. Michael R Hamblin

70

Research Journal of Textile and Apparel

Improved grip strength

2019

Grip Strength

Effect of Shirts with 42% CELLIANT® Fiber on tcPO2 Levels and Grip Strength in Healthy Subjects: A Placebo-Controlled Clinical Trial

Long Beach VA Memorial Hospital

Dr. Ian Gordon, Dr. Mark Vangel and Dr. Michael R Hamblin

24

Journal of Textile Science and Engineering

Improved grip strength of over 12% in the dominant hand after 90 minutes

2018

Tissue Oxygen (TCPO2)

Randomized Controlled Trial Comparing the Effects of Far-Infrared Emitting Ceramic Fabric Shirts and Control Polyester Shirts on Transcutaneous PO2

Long Beach VA Memorial Hospital

Dr. Ian Gordon, James Wason, Dr. Lawrence Lavery, Dr. Michael R Hamblin and MS Thein

153

Journal of Textile Science and Engineering

Average increase in TCPO2 of 8.4% after 90 minutes for 71% of the subjects

2012

Tissue Oxygen (TCPO2)

The Test Report on the Impacts of Subject Socks with the Application of CELLIANT® Technical Fibers on Transcutaneous Oxygen Pressure on a Man’s Foot

Academy of Chinese Sciences

Dr. Li Shaojing, Wu Chuanhong, Gao Jian, Zhu Li and Wen Liwei

100

N/A

Increase in TCPO2 across all healthy subjects

2012

Tissue Oxygen (TCPO2)

Transcutaneous Partial Pressure of Oxygen (tcPO2) as a Primary Endpoint to Assess the Efficacy of CELLIANT® as a Vasoactive Material

Long Beach VA Memorial Hospital

Dr. Ian Gordon and Dr. Michael Coyle

51

N/A

An average increase of 7% in TCPO2

2011

Performance & Recovery

Apparel with Far Infrared Radiation for Decreasing an Athlete’s Oxygen Consumption During Submaximal Exercise

University of Calgary

Dr. Jay Worobets, Dr. Darren Stefanyshyn and Emma Skolnik

12

Research Journal of Textile and Apparel
Elite/club cyclists VO2 reduced by 1.1%, increasing anaerobic threshold

2010

Sleep (pilot)
Double Blind, Placebo Controlled, Crossover Trial on the Effect of Optically Modified Polyethylene Terephthalate Fiber Mattress Covers on Sleep Disturbances in Patients with Chronic Back Pain
University of CA Irvine
Dr. Marcel Hungs and Dr. Annabel Wang

6

N/A

Nighttime awakenings, sleep quality and sleep efficiency improved

2009

Foot Pain

Effect of Optically Modified Polyethylene Terephthalate Fiber Socks on Chronic Foot Pain

University of CA Irvine

Dr. Ian Gordon and Dr. Robyn York

55

BioMed Central Complementary & Alternative Medicine
Statistically significant reduction of pain and improved comfort for subjects (diabetic/foot neuropathy)

2005

Tissue Oxygen (TCPO2)

Holofiber Study of Thirteen (13) Healthy Subjects

University of Texas A&M

Dr. Graham McClue

13

N/A

An average increase in TCPO2 levels from 10% to 24%

2003

Tissue Oxygen (TCPO2)

Improving Blood Flow with Holofiber in the Hands and Feet of High-Risk Diabetics

Loyola University Chicago

Dr. Lawrence Lavery

20

N/A
An average increase in TCPO2 levels from 12% in the hands and 8% in the feet of diabetic subjects
green divider line
green divider line
Close-up of intricate weaving threads on a loom.

MECHANICAL TESTING LIBRARY

In addition to our clinical trial research, CELLIANT has undergone a variety of mechanical tests, including ash analysis, dry rate, emissivity properties, heat and insulation and UV protection. These reports highlight the unique properties of CELLIANT as a textile ingredient.

CONTINUED RESEARCH & DEVELOPMENT

Hologenix is committed to expanding the available body of research on IR-emitting textiles and the benefits of infrared light therapy. If you are interested in partnering with us, whether to share protocol, outcomes and ideas, or looking to utilize CELLIANT infrared technology as part of your own body of research, we would be happy to collaborate. Please reach out to our testing team via testing@celliant.com.

Two scientists wearing lab coats and blue gloves shaking hands in a bright laboratory.

WANT TO LEARN MORE?

For a full-spectrum experience, find related reading about similar topics below.

FAQs

Infrared, sometimes called infrared light, is electromagnetic energy with wavelengths longer than those of visible light, that make it invisible to the human eye. The benefits of infrared on the human body have been shown to help the body thermoregulate more effectively, to increase energy, endurance and stamina, to improve performance and comfort, and to aid in a more restful sleep.
You can trust that CELLIANT works because of our commitment to scientific research. CELLIANT has a Science Advisory Board that works with primary investigators to rigorously test and validate the science of infrared and its benefits. This includes experts in the fields of photobiology, nanotechnology, sleep medicine, human physiology, diabetes and wound care. To date, Hologenix has 10 peer-reviewed published studies.

The increase in tissue oxygenation will be measurable anywhere from 5-30 minutes from use.

For all practical purposes when you are no longer in close proximity to the CELLIANT product, you will stop getting its direct benefits.

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