CLINICAL TRIALS

The Science Advisory Board works with primary investigators to rigorously test and validate the science of infrared and its benefits. This includes experts in photobiology, nanotechnology, sleep medicine, human physiology, diabetes and wound care. To date, Hologenix has 10 peer-reviewed published studies.

CLINICALLY DEMONSTRATED BENEFITS

Download a summary of our pre-clinical, clinical and physical trials, including an overview of the primary investigators, endpoints and outcomes.

Download a full report that contains a compilation of CELLIANT®’s peer-reviewed published studies in their entirety.

CLINICALLY DEMONSTRATED BENEFITS

Download a summary of our pre-clinical, clinical and physical trials, including an overview of the primary investigators, endpoints and outcomes.

Download a full report that contains a compilation of CELLIANT®’s peer-reviewed published studies in their entirety.

CLINICAL, PRECLINICAL, TECHNICAL AND PHYSICAL TRIALS

Effect of Shirts with 42% CELLIANT® Fiber on tcPO2 Levels and Grip Strength in Healthy Subjects: A Placebo-Controlled Clinical Trial

Randomized Controlled Trial Comparing the Effects of Far-Infrared Emitting Ceramic Fabric Shirts and Control Polyester Shirts on Transcutaneous PO2

Effect of CELLIANT® Armbands on Grip Strength in Grip Strength in Subjects with Chronic Wrist and Elbow Pain

The Test Report on the Impacts of Subject Socks with the Application of CELLIANT® Technical Fibers on Transcutaneous Oxygen Pressure on a Man’s Foot

Transcutaneous Partial Pressure of Oxygen (tcPO2) as a Primary Endpoint to Assess the Efficacy of CELLIANT® as a Vasoactive Material

Apparel with Far Infrared Radiation for Decreasing an Athlete’s Oxygen Consumption During Submaximal Exercise

Double Blind, Placebo Controlled, Crossover Trial on the Effect of Optically Modified Polyethylene Terephthalate Fiber Mattress Covers on Sleep Disturbances in Patients with Chronic Back Pain

Effect of Optically Modified Polyethylene Terephthalate Fiber Socks on Chronic Foot Pain

Holofiber Study of Thirteen (13) Healthy Subjects
Improving Blood Flow with Holofiber in the Hands and Feet of High-Risk Diabetics

Infrared Radiative Properties and Thermal Modeling of Ceramic-Embedded Textile Fabrics

Engineered Emissivity of Textile Fabrics by the Inclusion of Ceramic Particles
Far Infrared Radiation (FIR): Its Biological Effects and Medical Applications

CELLIANT Bedding Moderates Autoimmune and Inflammatory Responses

Randomized Placebo-Controlled Clinical Trial of Gloves and Stockings Made from Infrared-Emitting Fabric (CELLIANT®️) for Transcutaneous Oxygen and Peripheral Blood Flow in Diabetic Patients with Vascular Impairment

SUMMARY OF CLINICAL TRIALS

Year

End Point

Title

Institution

Primary Investigators

N

Journal/Publication

Outcome

2022

Tissue Oxygen (TCPO2) and Peripheral Blood Flow

Randomized Placebo-Controlled Clinical Trial of Gloves and Stockings Made from Infrared-Emitting Fabric (CELLIANT®) for Transcutaneous Oxygen and Peripheral Blood Flow in Diabetic Patients with Vascular Impairment

Loyola University Chicago

Dr. Lawrence A. Lavery, Dr. Michael R. Hamblin and Kathryn Davis

20

Journal of Textile Science & Engineering

Initial findings suggest evidence of improvement in peripheral blood flow of diabetic patients

2021

Elbow and Wrist Pain

Effect of CELLIANT® Armbands on Grip Strength in Grip Strength in Subjects with Chronic Wrist and Elbow Pain

Long Beach VA Memorial Hospital

Dr. Ian Gordon and Dr. Michael R Hamblin

70

Research Journal of Textile and Apparel

Improved grip strength

2019

Grip Strength

Effect of Shirts with 42% CELLIANT® Fiber on tcPO2 Levels and Grip Strength in Healthy Subjects: A Placebo-Controlled Clinical Trial

Long Beach VA Memorial Hospital

Dr. Ian Gordon, Dr. Mark Vangel and Dr. Michael R Hamblin

24

Journal of Textile Science and Engineering

Improved grip strength of over 12% in the dominant hand after 90 minutes

2018

Tissue Oxygen (TCPO2)

Randomized Controlled Trial Comparing the Effects of Far-Infrared Emitting Ceramic Fabric Shirts and Control Polyester Shirts on Transcutaneous PO2

Long Beach VA Memorial Hospital

Dr. Ian Gordon, James Wason, Dr. Lawrence Lavery, Dr. Michael R Hamblin and MS Thein

153

Journal of Textile Science and Engineering

Average increase in TCPO2 of 8.4% after 90 minutes for 71% of the subjects

2012

Tissue Oxygen (TCPO2)

The Test Report on the Impacts of Subject Socks with the Application of CELLIANT® Technical Fibers on Transcutaneous Oxygen Pressure on a Man’s Foot

Academy of Chinese Sciences

Dr. Li Shaojing, Wu Chuanhong, Gao Jian, Zhu Li and Wen Liwei

100

N/A

Increase in TCPO2 across all healthy subjects

2012

Tissue Oxygen (TCPO2)

Transcutaneous Partial Pressure of Oxygen (tcPO2) as a Primary Endpoint to Assess the Efficacy of CELLIANT® as a Vasoactive Material

Long Beach VA Memorial Hospital

Dr. Ian Gordon and Dr. Michael Coyle

51

N/A

An average increase of 7% in TCPO2

2011

Performance & Recovery

Apparel with Far Infrared Radiation for Decreasing an Athlete’s Oxygen Consumption During Submaximal Exercise

University of Calgary

Dr. Jay Worobets, Dr. Darren Stefanyshyn and Emma Skolnik

12

Research Journal of Textile and Apparel
Elite/club cyclists VO2 reduced by 1.1%, increasing anaerobic threshold

2010

Sleep (pilot)
Double Blind, Placebo Controlled, Crossover Trial on the Effect of Optically Modified Polyethylene Terephthalate Fiber Mattress Covers on Sleep Disturbances in Patients with Chronic Back Pain
University of CA Irvine
Dr. Marcel Hungs and Dr. Annabel Wang

6

N/A

Nighttime awakenings, sleep quality and sleep efficiency improved

2009

Foot Pain

Effect of Optically Modified Polyethylene Terephthalate Fiber Socks on Chronic Foot Pain

University of CA Irvine

Dr. Ian Gordon and Dr. Robyn York

55

BioMed Central Complementary & Alternative Medicine
Statistically significant reduction of pain and improved comfort for subjects (diabetic/foot neuropathy)

2005

Tissue Oxygen (TCPO2)

Holofiber Study of Thirteen (13) Healthy Subjects

University of Texas A&M

Dr. Graham McClue

13

N/A

An average increase in TCPO2 levels from 10% to 24%

2003

Tissue Oxygen (TCPO2)

Improving Blood Flow with Holofiber in the Hands and Feet of High-Risk Diabetics

Loyola University Chicago

Dr. Lawrence Lavery

20

N/A
An average increase in TCPO2 levels from 12% in the hands and 8% in the feet of diabetic subjects

SUMMARY OF CLINICAL TRIALS

Year

2022

End Point

Tissue Oxygen (TCPO2) and Peripheral Blood Flow

Title

Randomized Placebo-Controlled Clinical Trial of Gloves and Stockings Made from Infrared-Emitting Fabric (CELLIANT®) for Transcutaneous Oxygen and Peripheral Blood Flow in Diabetic Patients with Vascular Impairment

Institution

Loyola University Chicago

Primary Investigators

Dr. Lawrence A. Lavery, Dr. Michael R. Hamblin and Kathryn Davis

N

20

Journal/Publication

Journal of Textile Science & Engineering

Outcome
Initial findings suggest evidence of improvement in peripheral blood flow of diabetic patients

Year

2021

End Point

Elbow and Wrist Pain

Title

Effect of CELLIANT® Armbands on Grip Strength in Grip Strength in Subjects with Chronic Wrist and Elbow Pain

Institution

Long Beach VA Memorial Hospital

Primary Investigators

Dr. Ian Gordon and Dr. Michael R Hamblin

N

70

Journal/Publication

Research Journal of Textile and Apparel

Outcome
Improved grip strength

Year

2019

End Point

Grip Strength

Title

Effect of Shirts with 42% CELLIANT® Fiber on tcPO2 Levels and Grip Strength in Healthy Subjects: A Placebo-Controlled Clinical Trial

Institution

Long Beach VA Memorial Hospital

Primary Investigators

Dr. Ian Gordon, Dr. Mark Vangel and Dr. Michael R Hamblin

N

24

Journal/Publication

Journal of Textile Science and Engineering

Outcome
Improved grip strength of over 12% in the dominant hand after 90 minutes

Year

2018

End Point

Tissue Oxygen (TCPO2)

Title

Randomized Controlled Trial Comparing the Effects of Far-Infrared Emitting Ceramic Fabric Shirts and Control Polyester Shirts on Transcutaneous PO2

Institution

Long Beach VA Memorial Hospital

Primary Investigators

Dr. Ian Gordon, James Wason, Dr. Lawrence Lavery, Dr. Michael R Hamblin and MS Thein

N

153

Journal/Publication

Journal of Textile Science and Engineering

Outcome
Average increase in TCPO2 of 8.4% after 90 minutes for 71% of the subjects

Year

2012

End Point

Tissue Oxygen (TCPO2)

Title

The Test Report on the Impacts of Subject Socks with the Application of CELLIANT® Technical Fibers on Transcutaneous Oxygen Pressure on a Man’s Foot

Institution

Academy of Chinese Sciences

Primary Investigators

Dr. Li Shaojing, Wu Chuanhong, Gao Jian, Zhu Li and Wen Liwei

N

100

Journal/Publication

N/A

Outcome
Increase in TCPO2 across all healthy subjects

Year

2012

End Point

Tissue Oxygen (TCPO2)

Title

Transcutaneous Partial Pressure of Oxygen (tcPO2) as a Primary Endpoint to Assess the Efficacy of CELLIANT® as a Vasoactive Material

Institution

Long Beach VA Memorial Hospital

Primary Investigators

Dr. Ian Gordon and Dr. Michael Coyle

N

51

Journal/Publication

N/A

Outcome
An average increase of 7% in TCPO2

Year

2011

End Point

Performance & Recovery

Title

Apparel with Far Infrared Radiation for Decreasing an Athlete’s Oxygen Consumption During Submaximal Exercise

Institution

University of Calgary

Primary Investigators

Dr. Jay Worobets, Dr. Darren Stefanyshyn and Emma Skolnik

N

12

Journal/Publication

Research Journal of Textile and Apparel
Outcome
Elite/club cyclists VO2 reduced by 1.1%, increasing anaerobic threshold

Year

2010

End Point

Sleep (pilot)

Title

Double Blind, Placebo Controlled, Crossover Trial on the Effect of Optically Modified Polyethylene Terephthalate Fiber Mattress Covers on Sleep Disturbances in Patients with Chronic Back Pain

Institution

University of CA Irvine

Primary Investigators

Dr. Marcel Hungs and Dr. Annabel Wang

N

6

Journal/Publication

N/A

Outcome
Nighttime awakenings, sleep quality and sleep efficiency improved

Year

2009

End Point

Foot Pain

Title

Effect of Optically Modified Polyethylene Terephthalate Fiber Socks on Chronic Foot Pain

Institution

University of CA Irvine

Primary Investigators

Dr. Ian Gordon and Dr. Robyn York

N

55

Journal/Publication

BioMed Central Complementary & Alternative Medicine
Outcome
Statistically significant reduction of pain and improved comfort for subjects (diabetic/foot neuropathy)

Year

2005

End Point

Tissue Oxygen (TCPO2)

Title

Holofiber Study of Thirteen (13) Healthy Subjects

Institution

University of Texas A&M

Primary Investigators

Dr. Graham McClue

N

13

Journal/Publication

N/A
Outcome

An average increase in TCPO2 levels from 10% to 24%

Year

2003

End Point

Tissue Oxygen (TCPO2)

Title

Improving Blood Flow with Holofiber in the Hands and Feet of High-Risk Diabetics

Institution

Loyola University Chicago

Primary Investigators

Dr. Lawrence Lavery

N

20

Journal/Publication

N/A
Outcome
An average increase in TCPO2 levels from 12% in the hands and 8% in the feet of diabetic subjects

SUMMARY OF PRECLINICAL TRIAL

Year

End Point

Title

Institution

Primary Investigators

Journal/Publication

Outcome

2021

Anti-inflammatory Markers and Improved Motion
CELLIANT Bedding Moderates Autoimmune and Inflammatory Responses
University of Belgrade
Dr. Jasmina Djuretic, Dr. Mirjana Dimitrijevic, Dr. Marija Stojanovic, Dr. Jelena Kotur Stevuljevic, Dr. Michael R Hamblin, Dr. Ana Micov, Dr. Radica Stepanovic-Petrovic and Dr. Gordana Leposavic
Scientific Reports
The appearance of the symptoms of collagen type II induced arthritis was postponed, while the disease was milder in infrared radiation exposed rats compared to nonexposed rats. Objective biochemical measurements of cytokines and autoimmunity were improved.

SUMMARY OF PRECLINICAL TRIAL

Year

2021

Title

CELLIANT Bedding Moderates Autoimmune and Inflammatory Responses

End Point

Anti-inflammatory Markers and Improved Motion

Institution

University of Belgrade

Primary Investigators

Dr. Jasmina Djuretic, Dr. Mirjana Dimitrijevic, Dr. Marija Stojanovic, Dr. Jelena Kotur Stevuljevic, Dr. Michael R Hamblin, Dr. Ana Micov, Dr. Radica Stepanovic-Petrovic and Dr. Gordana Leposavic

Journal/Publication

Scientific Reports

Outcome
The appearance of the symptoms of collagen type II induced arthritis was postponed, while the disease was milder in infrared radiation exposed rats compared to nonexposed rats. Objective biochemical measurements of cytokines and autoimmunity were improved.

SUMMARY OF TECHNICAL & PHYSICAL TRIALS

Year

End Point

Title

Institution

Primary Investigators

Journal/Publication

Outcome

2017

Solar IR Emissivity

Infrared Radiative Properties and Thermal Modeling of Ceramic-Embedded Textile Fabrics

Exponent

Dr. David Anderson, John Fessler, Matthew Pooley, Scott Seidel, Dr. Michael R Hamblin, Haskell Beckham and Dr. James F Brennan

Biomedical Optics Express

Emissivity increased by approximately 10x when sunlight is also used to power CELLIANT technology

2016

IR Emissivity

Engineered Emissivity of Textile Fabrics by the Inclusion of Ceramic Particles

Exponent

Dr. David M. Anderson, Matthew Pooley, Haskell W. Beckham and Dr. James F Brennan

Optics Express

Emissivity increased by .14 MW per CM2 at fabric temperature of 32 Celsius with a 42% CELLIANT fabric vs. control

2012

Principals of IR

Far Infrared Radiation (FIR): Its Biological Effects and Medical Applications

Harvard/Wellman Center for Photomedicine

Dr. Michael R Hamblin and Dr. Fatma Vatansever

Photonics and Lasers in Medicine

Far Infrared Radiation (FIR) its biological effects and medical applications

SUMMARY OF TECHNICAL & PHYSICAL TRIALS

Year

2017

Title

Solar IR Emissivity

End Point

Infrared Radiative Properties and Thermal Modeling of Ceramic-Embedded Textile Fabrics

Institution

Exponent

Primary Investigators

Dr. David Anderson, John Fessler, Matthew Pooley, Scott Seidel, Dr. Michael R Hamblin, Haskell Beckham and Dr. James F Brennan

Journal/Publication

Biomedical Optics Express

Outcome
Emissivity increased by approximately 10x when sunlight is also used to power CELLIANT technology

Year

2016

Title

IR Emissivity

End Point

Engineered Emissivity of Textile Fabrics by the Inclusion of Ceramic Particles

Institution

Exponent

Primary Investigators

Dr. David M. Anderson, Matthew Pooley, Haskell W. Beckham and Dr. James F Brennan

Journal/Publication

Optics Express

Outcome
Emissivity increased by .14 MW per CM2 at fabric temperature of 32 Celsius with a 42% CELLIANT fabric vs. control

Year

2012

Title

Principals of IR

End Point

Far Infrared Radiation (FIR): Its Biological Effects and Medical Applications

Institution

Harvard/Wellman Center for Photomedicine

Primary Investigators

Dr. Michael R Hamblin and Dr. Fatma Vatansever

Journal/Publication

Photonics and Lasers in Medicine

Outcome
Far Infrared Radiation (FIR) its biological effects and medical applications

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